ZX-7101A potently inhibits cap-dependent endonuclease (CEN) in the PA proteins of influenza A and B viruses. Its pharmacological property is suitable for a single dose to treat and prevent influenza A and B virus infections.

In preclinical studies, ZX-7101A demonstrated superior efficacy against anti-influenza virus over Oseltamivir, and comparable efficacy with Xofluza. Not like Xofluza, ZX-7101A showed no food effect on oral bioavailability, and potentially has better safety and efficacy in the clinic.

ZX-7101A is currently in New Drug Application (NDA) in China.

PI3Kγ is a molecular switch that controls immune suppression and activates integrin α4 and promotes immune suppressive myeloid polarization during tumor progression. It was demonstrated that inhibition of PI3Kγ overcomes resistance to checkpoint blockade therapy.

ZX-4081 is the most selective and potent PI3Kγ inhibitor up to date. In preclinical studies, it showed favorable pharmacokinetic profile and efficacy was confirmed in solid tumor models. ZX-4081 is on the way to become best-in-class PI3Kγ inhibitor for the treatment of solid tumors, either as single agent or combination with other anticancer agents.

ZX-4081 is currently in Phase I clinical trial development in the United States.

ZX-101A is a next-generation of PI3Kδ/γ inhibitor with improved therapeutic window in pre-clinical models. ZX-101A doesn’t carry the purine motif common in Idelalisib & and Duvelisib and minimize the drug-drug interaction potential in combination therapies or in use with concomitant medications. Dual inhibition of PI3Kδ and PI3Kγ by ZX-101A as the treatment of hematologic malignancies may synergistically exert through directly inhibiting PI3K signaling in malignant lymphocytes and enhancing anti-tumor immunity. ZX-101A has the potential to be the best-in-class medicine for blood cancers as well as the first-in-class immune-oncology treatment to certain solid tumors.

The Phase I/IIa clinical trials for patients with relapsed/refractory solid tumors and hematological malignancies are ongoing in China and US.

Ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1), has been discovered as the predominant enzyme hydrolyzing 2’3’-cGAMP, substrate of STING. ZX-8177 is a highly potent ENPP1 inhibitor which effectively induces IFN-β1 production and recruits M1 macrophages, NK cells and CD8+T cells to infiltrate the tumor immune microenvironment (TIME) to suppress tumor progression. In preclinical studies, ZX-8177 has exhibited synergistic anti-tumor effects in combination with conventional therapies such as chemo and radiotherapies, which may provide an effective cancer treatment overcoming the resistance and the common side effects.

ZX-8177 is approved clinical trials in China for the treatment of advanced solid tumors.